A structural overview of mycobacterial adhesins: Key biomarkers for diagnostics and therapeutics.

ABSTRACT: Adherence, colonization, and survival of mycobacteria in host cells require surface adhesins, which are attractive pharmacotherapeutic targets. A large arsenal of pilus and non-pilus adhesins have been identified in mycobacteria. These adhesins are capable of interacting with host cells, including macrophages and epithelial cells and are essential to microbial pathogenesis. In the last decade, several structures of mycobacterial adhesins responsible for adhesion to either macrophages or extra cellular matrix proteins have been elucidated. In addition, key structural and functional information have emerged for the process of mycobacterial adhesion to epithelial cells, mediated by the Heparin-binding hemagglutinin (HBHA). In this review, we provide an overview of the structural and functiona

SUBMITTER: Squeglia F 

PROVIDER: S-EPMC5775178 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature