Designing a B Cell-Based Vaccine against a Highly Variable Hepatitis C Virus.

ABSTRACT: The ability to use structure-based design and engineering to control the molecular shape and reactivity of an immunogen to induce protective responses shows great promise, along with corresponding advancements in vaccine testing and evaluation systems. We describe in this review new paradigms for the development of a B cell-based HCV vaccine. Advances in test systems to measure in vitro and in vivo antibody-mediated virus neutralization include retroviral pseudotype particles expressing HCV E1E2 glycoproteins (HCVpp), infectious cell culture-derived HCV virions (HCVcc), and surrogate animal models mimicking acute HCV infection. Their applications have established the role of broadly neutralizing antibodies to control HCV infection. However, the virus has immunogenic regions i

SUBMITTER: Fuerst TR 

PROVIDER: S-EPMC5775222 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature