Role of subcortical structures on cognitive and social function in schizophrenia.

ABSTRACT: Subcortical regions have a pivotal role in cognitive, affective, and social functions in humans, and the structural and functional abnormalities of the regions have been associated with various psychiatric disorders. Although previous studies focused on the neurocognitive and socio-functional consequences of prefrontal and tempolo-limbic abnormalities in psychiatric disorders, those of subcortical structures remain largely unknown. Recently, MRI volume alterations in subcortical structures in patients with schizophrenia have been replicated in large-scale meta-analytic studies. Here we investigated the relationship between volumes of subcortical structures and neurocognitive and socio-functional indices in a large sample of patients with schizophrenia. First, we replicated the results of m

SUBMITTER: Koshiyama D 

PROVIDER: S-EPMC5775279 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature