Epigenetic control of influenza virus: role of H3K79 methylation in interferon-induced antiviral response.

ABSTRACT: Influenza virus stablishes a network of virus-host functional interactions, which depends on chromatin dynamic and therefore on epigenetic modifications. Using an unbiased search, we analyzed the epigenetic changes at DNA methylation and post-translational histone modification levels induced by the infection. DNA methylation was unaltered, while we found a general decrease on histone acetylation, which correlates with transcriptional inactivation and may cooperate with the impairment of cellular transcription that causes influenza virus infection. A particular increase in H3K79 methylation was observed and the use of an inhibitor of the specific H3K79 methylase, Dot1L enzyme, or its silencing, increased influenza virus replication. The antiviral response was reduced in conditions of Dot1L

SUBMITTER: Marcos-Villar L 

PROVIDER: S-EPMC5775356 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature