Binding of α_vβ₃ Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status.

ABSTRACT:

Purpose

Molecular imaging of α_vβ₃ integrin has exhibited real potential to guide the appropriate use of anti-angiogenic therapies. However, an incomplete understanding of the factors that influence binding of α_vβ₃ integrin-specific radiotracers currently limits their use for assessing response to therapy in cancer patients. This study identifies two fundamental factors that modulate uptake of these radiotracers. Procedures Experiments were performed in prostate cancer (PC3) and glioblastoma (U87MG) cells, which differentially express α_vβ₃ integrin. α_vβ₃ integrin-specific radiotracers were used to investigate the effect of manipulating α_vβ₃ integrin expression or activation

SUBMITTER: Andriu A 

PROVIDER: S-EPMC5775384 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature