The histone code reader Spin1 controls skeletal muscle development.

ABSTRACT: While several studies correlated increased expression of the histone code reader Spin1 with tumor formation or growth, little is known about physiological functions of the protein. We generated Spin1^M5 mice with ablation of Spin1 in myoblast precursors using the Myf5-Cre deleter strain. Most Spin1^M5 mice die shortly after birth displaying severe sarcomere disorganization and necrosis. Surviving Spin1^M5 mice are growth-retarded and exhibit the most prominent defects in soleus, tibialis anterior, and diaphragm muscle. Transcriptome analyses of limb muscle at embryonic day (E) 15.5, E16.5, and at three weeks of age provided evidence for aberrant fetal myogenesis and identified deregulated skeletal muscle (SkM) functional networks. Determination of genome-wide

SUBMITTER: Greschik H 

PROVIDER: S-EPMC5775400 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature