Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma.

ABSTRACT: Glioma is a unique neoplastic disease that develops exclusively in the central nervous system (CNS) and rarely metastasizes to other tissues. This feature strongly implicates the tumor-host CNS microenvironment in gliomagenesis and tumor progression. We investigated the differences and similarities in glioma biology as conveyed by transcriptomic patterns across four mammalian hosts: rats, mice, dogs, and humans. Given the inherent intra-tumoral molecular heterogeneity of human glioma, we focused this study on tumors with upregulation of the platelet-derived growth factor signaling axis, a common and early alteration in human gliomagenesis. The results reveal core neoplastic alterations in mammalian glioma, as well as unique contributions of the tumor host to neoplastic processes. Notable d

SUBMITTER: Connolly NP 

PROVIDER: S-EPMC5775420 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature