Population size may shape the accumulation of functional mutations following domestication.

ABSTRACT:

Background

Population genetics theory predicts an important role of differences in the effective population size (N _e ) among species on shaping the accumulation of functional mutations by regulating the selection efficiency. However, this correlation has never been tested in domesticated animals.

Results

Here, we synthesized 62 whole genome data in eight domesticated species (cat, dog, pig, goat, sheep, chicken, cattle and horse) and compared domesticates with their wild (or ancient) relatives. Genes with significantly different selection pressures (revealed by nonsynonymous/synonymous substitution rate ratios, Ka/Ks or ω) between domesticated (D_ω) and wild animals (W_ω) were determined by likelihood-ratio tests. Species-level effective popul

SUBMITTER: Chen J 

PROVIDER: S-EPMC5775542 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature