A study of the association of rs12040273 with susceptibility and severity of coronary artery disease in a Chinese Han population.

ABSTRACT:

Background

The single nucleotide polymorphism (SNP) rs12040273, a variant of UDP-N-acetylgalactosamine, polypeptide GalNAc-transferase 2, has recently been reported to be significantly associated with development of carotid artery intima-media thickness (IMT) in a Chinese population based on a genome-wide association study. Because IMT is a potent marker of coronary artery disease (CAD), the aim of this study was to evaluate the relation of rs12040273 to susceptibility and severity of CAD in a Chinese Han population.

Methods

We performed a hospital-based case-control study. Three hundred and thirty-one individuals (199 CAD patients and 112 non-CAD controls) undergoing coronary angiography were consecutively enrolled in the study. The Gensini score results were used to assess

SUBMITTER: Yang B 

PROVIDER: S-EPMC5775593 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature