Prognostic role of HSF1 overexpression in solid tumors: a pooled analysis of 3,159 patients.

ABSTRACT:

Background and objective

HSF1 is reported to be overexpressed in various solid tumors and play a pivotal role in cancer progression. A meta-analysis was conducted to assess the potential prognostic role of HSF1 in patients with solid tumors.

Methods

An extensive electronic search of three databases was performed for relevant articles. The pooled hazard ratios (HRs) or odds ratios with their corresponding 95% CI were calculated with a random-effects model. Heterogeneity and publication bias analyses were also conducted.

Results

A total of 3,159 patients from 10 eligible studies were included into the analysis. The results showed that positive HSF1 expression was significantly correlated with poor overall survival in all tumors (HR=2.09; 95% CI: 1.62-2.70; P<0.00

SUBMITTER: Wan T 

PROVIDER: S-EPMC5775745 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature