Differential Expression and Remodeling of Transient Outward Potassium Currents in Human Left Ventricles.

ABSTRACT:

Background

Myocardial, transient, outward currents, I_to, have been shown to play pivotal roles in action potential (AP) repolarization and remodeling in animal models. The properties and contribution of I_to to left ventricular (LV) repolarization in the human heart, however, are poorly defined.

Methods and results

Whole-cell, voltage-clamp recordings, acquired at physiological (35°C to 37°C) temperatures, from myocytes isolated from the LV of nonfailing human hearts identified 2 distinct transient currents, I_to,fast (I_to,f) and I_to,slow (I_to,s), with significantly (P<0.0001) different rates of recovery from inactivation and pharmacological sensitives: I

SUBMITTER: Johnson EK 

PROVIDER: S-EPMC5775893 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature