Metabolic assessment of a migraine model using relaxation-enhanced ¹ H spectroscopy at ultrahigh field.

ABSTRACT:

Purpose

This study evaluates biochemical imbalances in a rat model that reflects dysfunctional pathways in migraine. The high sensitivity and spectral dispersion available to ¹ H MRS at 21.1 T expands metabolic profiling in this migraine model to include lactate (Lac), taurine (Tau), aspartate, and Gly-a mixture of glycine, glutamine, and glutamate.

Methods

Sprague-Dawley male rats were administered in situ an intraperitoneal injection of nitroglycerin (NTG) to induce the migraine analogue or saline as a control. A selective relaxation-enhanced MR spectroscopy sequence was used to target upfield metabolites from a 4-mm³ voxel for 2.5 h after injection.

Results

Significant increases were evident for Lac as early as 10 min after NTG injection, peak

SUBMITTER: Abad N 

PROVIDER: S-EPMC5775911 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature