Traffic-related air pollution associations with cytokeratin-18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population.

ABSTRACT:

Introduction

Traffic-related air pollution causes fatty liver, inflammation and fibrosis in animal models, but there have been few studies in humans.

Objectives

To test the hypothesis that traffic-related air pollution causes non-alcoholic fatty liver disease (NAFLD) and increased markers for non-alcoholic steatohepatitis (NASH); and that NAFLD increases liver susceptibility to increased NASH risk.

Methods

Data collected prospectively from 74 overweight or obese children were obtained from the Yale Pediatric Obesity Clinic. Traffic-related air pollution was characterized as vehicle traffic volume on major roads within a 1 km residential buffer, and as residential nitrogen dioxide (NO₂ ) exposure. Outcomes were hepatic fat fraction (HFF) measured by magnetic

SUBMITTER: Hsieh S 

PROVIDER: S-EPMC5775922 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature