Epicardial adipose tissue density and volume are related to subclinical atherosclerosis, inflammation and major adverse cardiac events in asymptomatic subjects.

ABSTRACT:

Background

We investigated whether epicardial adipose tissue (EAT) volume and density are related to early atherosclerosis, plaque inflammation and major adverse cardiac events (MACE, cardiac death and myocardial infarction) in asymptomatic subjects.

Methods

EAT volume and density were quantified from non-contrast cardiac CT in 456 asymptomatic individuals (age 60.3 ± 8.3; 68% with CCS>0) from the prospective EISNER trial. EAT volume and density were examined in relation to coronary calcium score (CCS), inflammatory biomarkers and MACE.

Results

EAT volume was higher and EAT density lower in subjects with coronary calcium compared to subjects without [89 vs 74 cm³, p < 0.001] [-76.9 vs -75.7 HU,p = 0.024]. EAT volume was lowest in individuals with no coronar

SUBMITTER: Goeller M 

PROVIDER: S-EPMC5776050 | biostudies-literature | 2018 Jan - Feb

REPOSITORIES: biostudies-literature