Comprehensive Characterization of the RNA Editomes in Cancer Development and Progression.

ABSTRACT: RNA editing is a post-transcriptional event that leads to transcriptome diversity and has been shown to play important roles in tumorigenesis. However, dynamical changes and the functional significance of editing events during different cancer stages have not yet been characterized systematically. In this paper, we describe a comprehensive study of the RNA editome of four samples from different cancer stages for the same patient based on analysis of both whole-genome and transcriptome sequencing data. We identified 35,225 and 33,784 RNA editing events for poly(A)⁺ and poly(A)^- RNA sequencing data respectively in all four samples and show that 93 and 90% correspond to cancer stage-specific editing events. We also found that half of editing sites in 3' UTR of coding gen

SUBMITTER: Luo H 

PROVIDER: S-EPMC5776088 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature