DHEA supplementation improves endometrial HOXA-10 mRNA expression in poor responders.

ABSTRACT: OBJECTIVE:The study was planned to investigate whether DHEA supplementation had an impact on endometrial receptivity in women who were poor responders (POR). MATERIAL AND METHODS:Twenty-eight POR women who were undergoing hysteroscopy and five fertile control subjects were included. The POR women were equally subdivided into two separate groups as patients who were currently using DHEA and those who were not. Endometrial samples of the subjects were obtained during hysteroscopy at the late follicular phase. Expression levels of endometrial HOXA-10, HOXA-11, and LIF mRNA were measured with the using real-time polymerase chain reaction. Spontaneous clinical pregnancy rates were also noted. RESULTS:Compared with POR women who were not given DHEA, upregulated endometrial HOXA-10 (7.33-fold) an

SUBMITTER: Celik O 

PROVIDER: S-EPMC5776153 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature