EDC IMPACT: Reduced sperm counts in rats exposed to human relevant mixtures of endocrine disrupters.

ABSTRACT: Human semen quality is declining in many parts of the world, but the causes are ill defined. In rodents, impaired sperm production can be seen with early life exposure to certain endocrine-disrupting chemicals, but the effects of combined exposures are not properly investigated. In this study, we examined the effects of early exposure to the painkiller paracetamol and mixtures of human relevant endocrine-disrupting chemicals in rats. One mixture contained four estrogenic compounds; another contained eight anti-androgenic environmental chemicals and a third mixture contained estrogens, anti-androgens and paracetamol. All exposures were administered by oral gavage to time-mated Wistar dams rats (n = 16-20) throughout gestation and lactation. In the postnatal period, testicular histology was

SUBMITTER: Axelstad M 

PROVIDER: S-EPMC5776667 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature