Prospects and Challenges in the Development of a Norovirus Vaccine.

ABSTRACT:

Purpose

Norovirus is the leading cause of acute epidemic gastroenteritis among children under the age of 5 years and adults in the United States and in adults worldwide, accounting for an estimated 20% of episodes of acute gastroenteritis across all ages. No effective vaccine is presently available. This article provides an overview of the current state of norovirus vaccine development, emphasizing barriers and challenges in the development of an effective vaccine, correlates of protection used to assess vaccine efficacy, and the results of clinical trials of the major candidate vaccines.

Methods

We performed an unstructured literature review of published articles listed in PubMed in the field of norovirus vaccine development, with an emphasis on studies in humans.

Findin

SUBMITTER: Cortes-Penfield NW 

PROVIDER: S-EPMC5776706 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature