The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury.

ABSTRACT:

Background

Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the adult brain, and it plays important roles in modulating synaptic plasticity and synaptogenesis. This study attempted to elucidate the role of the BDNF variant rs6265 in emotional symptoms following mild traumatic brain injury (mTBI).

Methods

To investigate the association between BDNF Val66Met polymorphism (rs6265) and emotional symptoms in mTBI patients, we recruited 192 mTBI patients and evaluated their Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores in the first and sixth week after mTBI.

Results

The patients carrying the T allele of rs6265 had significantly higher BAI scores in the first week following mTBI. In addition, the patients carryin

SUBMITTER: Wang YJ 

PROVIDER: S-EPMC5776765 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature