Closing the loop on impulsivity via nucleus accumbens delta-band activity in mice and man.

ABSTRACT: Reward hypersensitization is a common feature of neuropsychiatric disorders, manifesting as impulsivity for anticipated incentives. Temporally specific changes in activity within the nucleus accumbens (NAc), which occur during anticipatory periods preceding consummatory behavior, represent a critical opportunity for intervention. However, no available therapy is capable of automatically sensing and therapeutically responding to this vulnerable moment in time when anticipation-related neural signals may be present. To identify translatable biomarkers for an off-the-shelf responsive neurostimulation system, we record local field potentials from the NAc of mice and a human anticipating conventional rewards. We find increased power in 1- to 4-Hz oscillations predominate during reward anticipat

SUBMITTER: Wu H 

PROVIDER: S-EPMC5776799 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature