Upregulated solute carrier family 37 member 1 in colorectal cancer is associated with poor patient outcome and metastasis.

ABSTRACT: Solute carrier (SLC) drug transporters exchange various molecules without energy from adenosine triphosphate hydrolysis, indicating an association with anticancer drug resistance. However, the expression and role of SLC transporters in malignant tumors has not yet been fully elucidated. Therefore, in the current study, the expression of SLC37A family genes was evaluated in patients with colorectal cancer (CRC), and it was revealed that SLC family 37 member 1 (SLC37A1) expression was significantly increased in tumorous tissues compared with that in non-tumorous tissues. The cases with upregulated expression of SLC37A1 by immunohistochemical staining were significantly associated with positive venous invasion and liver metastasis. Furthermore, upregulated SLC37A1 expression was associated wi

SUBMITTER: Kikuchi D 

PROVIDER: S-EPMC5776953 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature