Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes.

ABSTRACT: Cell encapsulation has been shown to hold promise for effective, long-term treatment of type 1 diabetes (T1D). However, challenges remain for its clinical applications. For example, there is an unmet need for an encapsulation system that is capable of delivering sufficient cell mass while still allowing convenient retrieval or replacement. Here, we report a simple cell encapsulation design that is readily scalable and conveniently retrievable. The key to this design was to engineer a highly wettable, Ca²⁺-releasing nanoporous polymer thread that promoted uniform in situ cross-linking and strong adhesion of a thin layer of alginate hydrogel around the thread. The device provided immunoprotection of rat islets in immunocompetent C57BL/6 mice in a short-term (1-mo) study, similar t

SUBMITTER: An D 

PROVIDER: S-EPMC5777032 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature