Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells.

ABSTRACT: Around the time of gastrulation in higher vertebrate embryos, inductive interactions direct cells to form central nervous system (neural plate) or sensory placodes. Grafts of different tissues into the periphery of a chicken embryo elicit different responses: Hensen's node induces a neural plate whereas the head mesoderm induces placodes. How different are these processes? Transcriptome analysis in time course reveals that both processes start by induction of a common set of genes, which later diverge. These genes are remarkably similar to those induced by an extraembryonic tissue, the hypoblast, and are normally expressed in the pregastrulation stage epiblast. Explants of this epiblast grown in the absence of further signals develop as neural plate border derivatives and eventually expres

SUBMITTER: Trevers KE 

PROVIDER: S-EPMC5777083 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature