Transcriptome profiling of cancer tissues in Chinese patients with gastric cancer by high-throughput sequencing.

ABSTRACT: Gastric cancer (GC) is the fifth most common malignancy and the third leading cause of cancer-associated mortality worldwide. Therefore, there is a requirement to identify sufficiently sensitive biomarkers for GC. Genome-wide screening of transcriptome dysregulation among cancerous and normal tissues may provide insights into the underlying molecular mechanisms of GC initiation and progression. At present, high-throughput sequencing techniques have begun to innovate biomedical studies. The RNA-seq method has become an advanced approach in medical studies; it is capable of the accurate detection of gene expression levels. The present study used RNA-seq to evaluate the transcriptional changes between tumor and matched normal samples, and these changes were confirmed by differentially express

SUBMITTER: Tian P 

PROVIDER: S-EPMC5777123 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature