Protein arginine methyltransferase 6 controls erythroid gene expression and differentiation of human CD34⁺ progenitor cells.

ABSTRACT: Hematopoietic differentiation is driven by transcription factors, which orchestrate a finely tuned transcriptional network. At bipotential branching points lineage decisions are made, where key transcription factors initiate cell type-specific gene expression programs. These programs are stabilized by the epigenetic activity of recruited chromatin-modifying cofactors. An example is the association of the transcription factor RUNX1 with protein arginine methyltransferase 6 (PRMT6) at the megakaryocytic/erythroid bifurcation. However, little is known about the specific influence of PRMT6 on this important branching point. Here, we show that PRMT6 inhibits erythroid gene expression during megakaryopoiesis of primary human CD34⁺ progenitor cells. PRMT6 is recruited to erythroid gene

SUBMITTER: Herkt SC 

PROVIDER: S-EPMC5777187 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature