Molecular mimicking of C-terminal phosphorylation tunes the surface dynamics of Ca_V1.2 calcium channels in hippocampal neurons.

ABSTRACT: L-type voltage-gated Ca_V1.2 calcium channels (Ca_V1.2) are key regulators of neuronal excitability, synaptic plasticity, and excitation-transcription coupling. Surface-exposed Ca_V1.2 distributes in clusters along the dendrites of hippocampal neurons. A permanent exchange between stably clustered and laterally diffusive extra-clustered channels maintains steady-state levels of Ca_V1.2 at dendritic signaling domains. A dynamic equilibrium between anchored and diffusive receptors is a common feature among ion channels and is crucial to modulate signaling transduction. Despite the importance of this fine regulatory system, the molecular mechanisms underlying the surface dynamics of Ca_V1.2 are completely unexplored. Here, we examined the dyna

SUBMITTER: Folci A 

PROVIDER: S-EPMC5777246 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature