Input-Specific NMDAR-Dependent Potentiation of Dendritic GABAergic Inhibition.

ABSTRACT: Preservation of a balance between synaptic excitation and inhibition is critical for normal brain function. A number of homeostatic cellular mechanisms have been suggested to play a role in maintaining this balance, including long-term plasticity of GABAergic inhibitory synapses. Many previous studies have demonstrated a coupling of postsynaptic spiking with modification of perisomatic inhibition. Here, we demonstrate that activation of NMDA-type glutamate receptors leads to input-specific long-term potentiation of dendritic inhibition mediated by somatostatin-expressing interneurons. This form of plasticity is expressed postsynaptically and requires both CaMKIIα and the β2 subunit of the GABA-A receptor. Importantly, this process may function to preserve dendritic inhibition, as genetic d

SUBMITTER: Chiu CQ 

PROVIDER: S-EPMC5777295 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature