CoMiniGut-a small volume in vitro colon model for the screening of gut microbial fermentation processes.

ABSTRACT: Driven by the growing recognition of the influence of the gut microbiota (GM) on human health and disease, there is a rapidly increasing interest in understanding how dietary components, pharmaceuticals and pre- and probiotics influence GM. In vitro colon models represent an attractive tool for this purpose. With the dual objective of facilitating the investigation of rare and expensive compounds, as well as an increased throughput, we have developed a prototype in vitro parallel gut microbial fermentation screening tool with a working volume of only 5 ml consisting of five parallel reactor units that can be expanded with multiples of five to increase throughput. This allows e.g., the investigation of interpersonal variations in gut microbial dynamics and the acquisition of l

SUBMITTER: Wiese M 

PROVIDER: S-EPMC5777374 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature