Clinical Trials Targeting Aging and Age-Related Multimorbidity.

ABSTRACT:

Background

There is growing interest in identifying interventions that may increase health span by targeting biological processes underlying aging. The design of efficient and rigorous clinical trials to assess these interventions requires careful consideration of eligibility criteria, outcomes, sample size, and monitoring plans.

Methods

Experienced geriatrics researchers and clinical trialists collaborated to provide advice on clinical trial design.

Results

Outcomes based on the accumulation and incidence of age-related chronic diseases are attractive for clinical trials targeting aging. Accumulation and incidence rates of multimorbidity outcomes were developed by selecting at-risk subsets of individuals from three large cohort studies of older individuals. These pro

SUBMITTER: Espeland MA 

PROVIDER: S-EPMC5777384 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature