Brain volume reduction after whole-brain radiotherapy: quantification and prognostic relevance.

ABSTRACT:

Background

Recent studies have questioned the value of adding whole-brain radiotherapy (WBRT) to stereotactic radiosurgery (SRS) for brain metastasis treatment. Neurotoxicity, including radiation-induced brain volume reduction, could be one reason why not all patients benefit from the addition of WBRT. In this study, we quantified brain volume reduction after WBRT and assessed its prognostic significance.

Methods

Brain volumes of 91 patients with cerebral metastases were measured during a 150-day period after commencing WBRT and were compared with their pretreatment volumes. The average daily relative change in brain volume of each patient, referred to as the "brain volume reduction rate," was calculated. Univariate and multivariate Cox regression analyses were performed to

SUBMITTER: Hoffmann C 

PROVIDER: S-EPMC5777481 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature