Assessment of Total Lesion Glycolysis by ¹⁸F FDG PET/CT Significantly Improves Prognostic Value of GEP and ISS in Myeloma.

ABSTRACT: Purpose: Fluorine-18 fluorodeoxyglucose positron emission tomography with CT attenuation correction (¹⁸F-FDG PET/CT) is useful in the detection and enumeration of focal lesions and in semiquantitative characterization of metabolic activity (glycolytic phenotype) by calculation of glucose uptake. Total lesion glycolysis (TLG) and metabolic tumor volume (MTV) have the potential to improve the value of this approach and enhance the prognostic value of disease burden measures. This study aims to determine whether TLG and MTV are associated with progression-free survival (PFS) and overall survival (OS), and whether they improve risk assessments such as International Staging System (ISS) stage and GEP70 risk.Experimental Design: 192 patients underwent whole body PET/CT i

SUBMITTER: McDonald JE 

PROVIDER: S-EPMC5777601 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature