Is tranexamic acid exposure related to blood loss in hip arthroplasty? A pharmacokinetic-pharmacodynamic study.

ABSTRACT:

Aims

Tranexamic acid (TXA) is an antifibrinolytic agent, decreasing blood loss in hip arthroplasty. The present study investigated the relationship between TXA exposure markers, including the time above the in vitro threshold reported for inhibition of fibrinolysis (10 mg l^-1 ), and perioperative blood loss.

Methods

Data were obtained from a prospective, double-blind, parallel-arm, randomized superiority study in hip arthroplasty. Patients received a preoperative intravenous bolus of TXA 1 g followed by a continuous infusion of either TXA 1 g or placebo over 8 h. A population pharmacokinetic study was conducted to quantify TXA exposure.

Results

In total, 827 TXA plasma concentrations were measured in 166 patients. A two-compartment model fitted the data bes

SUBMITTER: Lanoiselee J 

PROVIDER: S-EPMC5777664 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature