MRI-based Assessment of 3D Intrafractional Motion of Head and Neck Cancer for Radiation Therapy.

ABSTRACT:

Purpose

To determine the 3-dimensional (3D) intrafractional motion of head and neck squamous cell carcinoma (HNSCC).

Methods and materials

Dynamic contrast-enhanced magnetic resonance images from 56 patients with HNSCC in the treatment position were analyzed. Dynamic contrast-enhanced magnetic resonance imaging consisted of 3D images acquired every 2.9 seconds for 4 minutes 50 seconds. Intrafractional tumor motion was studied in the 3 minutes 43 seconds of images obtained after initial contrast enhancement. To assess tumor motion, rigid registration (translations only) was performed using a region of interest (ROI) mask around the tumor. The results were compared with bulk body motion from registration to all voxels. Motion was split into systematic motion and random motion.

SUBMITTER: Gurney-Champion OJ 

PROVIDER: S-EPMC5777665 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature