Effect of bupivacaine lozenges on oral mucositis pain: a randomized controlled multicenter phase II study.

ABSTRACT:

Introduction

A nonblinded parallel-group randomized controlled study investigated the efficacy and tolerability of repeated administration of a bupivacaine lozenge (25 mg) as pain management for oral mucositis pain in head and neck cancer patients as add-on to standard systemic pain management.

Objective

The primary end point was the difference between the intervention group (Lozenge group) and the Control group in daily mean pain scores in the oral cavity or pharynx (whichever was higher).

Method

Fifty patients from 2 hospitals in Denmark were randomized 1:1 to 7 days of treatment with bupivacaine lozenges (taken up to every 2 hours) plus standard pain treatment minus topical lidocaine (Lozenge group) or standard pain treatment including topical lidocaine (Control gr

SUBMITTER: Mogensen S 

PROVIDER: S-EPMC5777682 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature