Transcriptomic features of primary prostate cancer and their prognostic relevance to castration-resistant prostate cancer.

ABSTRACT: Although various mechanisms of castration-resistant prostate cancer (CRPC) have been discovered, reliable biomarkers for monitoring CRPC progression are lacking. We sought to identify molecules that predict the progression of advanced prostate cancer (AdvPC) into CRPC. The study used primary-site samples (N=45 for next-generation sequencing (NGS); N=243 for real-time polymerase chain reaction) from patients with prostate cancer (PC). Five public databases containing microarray data of AdvPC and CRPC samples were analyzed. The NGS data showed that each progression step in PC associated with distinct gene expression profiles. Androgen receptor (AR) associated with tumorigenesis, advanced progression, and progression into CRPC. Analysis of the paired and unpaired A

SUBMITTER: Yun SJ 

PROVIDER: S-EPMC5777737 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature