HMGA2 overexpression predicts relapse susceptibility of blastemal Wilms tumor patients.

ABSTRACT: Wilms tumor (WT) is an embryonal malignant neoplasm of the kidney that accounts for 6-7% of all childhood cancers. WT seems to derive from multipotent embryonic renal stem cells that have failed to differentiate properly. Since mechanisms underlying WT tumorigenesis remain largely unknown, the aim of this study was to explore the expression of embryonic stem cell (ESC) markers in samples of WT patients after chemotherapy treatment SIOP protocol, as the gene expression patterns of ESC are like those of most cancer cells. We found that expression of ESC markers is heterogeneous, and depends on histological WT components. Interestingly, among ESC markers, HMGA2 was expressed significantly stronger in the blastemal component than in the stromal and the normal kidney. Moreover, two subsets of p

SUBMITTER: Hontecillas-Prieto L 

PROVIDER: S-EPMC5777772 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature