A novel KCND3 mutation associated with early-onset lone atrial fibrillation.

ABSTRACT: Atrial fibrillation (AF) is the most common arrhythmia in the clinic. While previous studies have identified AF-associated mutations in several genes, the genetic basis for AF remains unclear. Here, we identified a novel T361S missense mutation in potassium voltage-gated channel, shal-related subfamily, member 3 (KCND3) from a Chinese Han family ancestor with lone AF. The wild-type (WT) or mutant T361S of K_v4.3 protein (encoded by KCND3) were co-expressed with the auxiliary subunit K⁺ channel-Interacting Protein (KChIP2) in HEK293 cells, and transient outward potassium current (I_to) were recorded using patch-clamp methods, and the surface or total protein levels of K_v4.3 were analyzed by western blot. I_to</

SUBMITTER: Huang Y 

PROVIDER: S-EPMC5777789 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature