Paradoxical response reversal of top-down modulation in cortical circuits with three interneuron types.

ABSTRACT: Pyramidal cells and interneurons expressing parvalbumin (PV), somatostatin (SST), and vasoactive intestinal peptide (VIP) show cell-type-specific connectivity patterns leading to a canonical microcircuit across cortex. Experiments recording from this circuit often report counterintuitive and seemingly contradictory findings. For example, the response of SST cells in mouse V1 to top-down behavioral modulation can change its sign when the visual input changes, a phenomenon that we call response reversal. We developed a theoretical framework to explain these seemingly contradictory effects as emerging phenomena in circuits with two key features: interactions between multiple neural populations and a nonlinear neuronal input-output relationship. Furthermore, we built a cortical circuit model w

SUBMITTER: Garcia Del Molino LC 

PROVIDER: S-EPMC5777826 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature