Long Term Effect of Intensive Lifestyle Intervention on Cerebral Blood Flow.

ABSTRACT:

Objectives

To determine whether long-term behavioral intervention targeting weight loss through increased physical activity and reduced caloric intake would alter cerebral blood flow (CBF) in individuals with type 2 diabetes mellitus.

Design

Postrandomization assessment of CBF.

Setting

Action for Health in Diabetes multicenter randomized controlled clinical trial.

Participants

Individuals with type 2 diabetes mellitus who were overweight or obese and aged 45 to 76 (N = 310).

Interventions

A multidomain intensive lifestyle intervention (ILI) to induce weight loss and increase physical activity for 8 to 11 years or diabetes support and education (DSE), a control condition.

Measurements

Participants underwent cognitive assessment and standardized bra

SUBMITTER: Espeland MA 

PROVIDER: S-EPMC5777883 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature