Enantioselective Iridium-Catalyzed Phthalide Formation through Internal Redox Allylation of Phthalaldehydes.

ABSTRACT: An inside job: Enantioselective phthalide synthesis was achieved through internal redox allylation of o-phthalaldehydes. Oxidative esterification is balanced by reductive carbonyl addition to achieve an overall redox-neutral process. This method enabled formal syntheses of ent-spirolaxine methyl ether and CJ-12,954.

SUBMITTER: Cabrera JM 

PROVIDER: S-EPMC5777894 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature