Core promoter information content correlates with optimal growth temperature.

ABSTRACT: The subtle mechanisms by which protein-DNA interactions remain functional across a wide range of temperatures are largely unknown. In this work, we manually curated available information relating fully sequenced archaeal genomes with organism growth temperatures. We built a motif that represents the core promoter of each species and calculated its information content. We then studied the relation between optimal growth temperature (OGT) and information content (IC) in the promoter region.We found a positive correlation between G + C content and OGT in tRNA regions and not in overall genome. Furthermore, we found that there is a positive correlation between information content and optimal growth temperatures in Archaea. This can't be explained by an increased C+G composition nor by other ob

SUBMITTER: Aptekmann AA 

PROVIDER: S-EPMC5777992 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature