Investigation of Candida parapsilosis virulence regulatory factors during host-pathogen interaction.

ABSTRACT: Invasive candidiasis is among the most life-threatening infections in patients in intensive care units. Although Candida albicans is the leading cause of candidaemia, the incidence of Candida parapsilosis infections is also rising, particularly among the neonates. Due to differences in their biology, these species employ different antifungal resistance and virulence mechanisms and also induce dissimilar immune responses. Previously, it has been suggested that core virulence effecting transcription regulators could be attractive ligands for future antifungal drugs. Although the virulence regulatory mechanisms of C. albicans are well studied, less is known about similar mechanisms in C. parapsilosis. In order to search for potential targets for future antifungal drugs against this species, w

SUBMITTER: Toth R 

PROVIDER: S-EPMC5777994 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature