Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.

ABSTRACT: Telomere length is a risk factor in disease and the dynamics of telomere length are crucial to our understanding of cell replication and vitality. The proliferation of whole genome sequencing represents an unprecedented opportunity to glean new insights into telomere biology on a previously unimaginable scale. To this end, a number of approaches for estimating telomere length from whole-genome sequencing data have been proposed. Here we present Telomerecat, a novel approach to the estimation of telomere length. Previous methods have been dependent on the number of telomeres present in a cell being known, which may be problematic when analysing aneuploid cancer data and non-human samples. Telomerecat is designed to be agnostic to the number of telomeres present, making it suited for the pur

SUBMITTER: Farmery JHR 

PROVIDER: S-EPMC5778012 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature