Human stem cells express pannexins.

ABSTRACT:

Objective

Pannexins are channel proteins important for the release of calcium and adenosine triphosphate, which are among other functions involved in early development. Here, the expression of pannexins was investigated in induced pluripotent stem cells derived from human cord blood endothelial cells (hCBiPS2), in hematopoietic stem cell-derived induced pluripotent stem cells (HSC_F1285_T-iPS2) and in human embryonic stem cells (HES-3). The expression of pannexin (Panx) 1-3 mRNAs was analyzed in all three undifferentiated stem cell lines. Stem cells then underwent undirected differentiation into embryoid bodies and were analyzed regarding expression of germ layer-specific genes.

Results

Panx1, Panx2, and Panx3 mRNAs were expressed in all undifferentiated stem cell lines inve

SUBMITTER: Hainz N 

PROVIDER: S-EPMC5778636 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature