ADMP controls the size of Spemann's organizer through a network of self-regulating expansion-restriction signals.

ABSTRACT: BACKGROUND:The bone morphogenetic protein (BMP) signaling gradient is central for dorsoventral patterning in amphibian embryos. This gradient is established through the interaction of several BMPs and BMP antagonists and modulators, some secreted by Spemann's organizer, a cluster of cells coordinating embryonic development. Anti-dorsalizing morphogenetic protein (ADMP), a BMP-like transforming growth factor beta ligand, negatively affects the formation of the organizer, although it is robustly expressed within the organizer itself. Previously, we proposed that this apparent discrepancy may be important for the ability of ADMP to scale the BMP gradient with embryo size, but how this is achieved is unclear. RESULTS:Here we report that ADMP acts in the establishment of the organizer via tempo

SUBMITTER: Leibovich A 

PROVIDER: S-EPMC5778663 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature