Starling forces drive intracranial water exchange during normal and pathological states.

ABSTRACT:

Aim

To quantify the exchange of water between cerebral compartments, specifically blood, tissue, perivascular pathways, and cerebrospinal fluid-filled spaces, on the basis of experimental data and to propose a dynamic global model of water flux through the entire brain to elucidate functionally relevant fluid exchange phenomena.

Methods

The mechanistic computer model to predict brain water shifts is discretized by cerebral compartments into nodes. Water and species flux is calculated between these nodes across a network of arcs driven by Hagen-Poiseuille flow (blood), Darcy flow (interstitial fluid transport), and Starling's Law (transmembrane fluid exchange). Compartment compliance is accounted for using a pressure-volume relationship to enforce the Monro-Kellie doctrine. T

SUBMITTER: Linninger AA 

PROVIDER: S-EPMC5778682 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature