Genome-wide DNA methylation profiling in whole blood reveals epigenetic signatures associated with migraine.

ABSTRACT:

Background

Migraine is a common heritable neurovascular disorder typically characterised by episodic attacks of severe pulsating headache and nausea, often accompanied by visual, auditory or other sensory symptoms. Although genome-wide association studies have identified over 40 single nucleotide polymorphisms associated with migraine, there remains uncertainty about the casual genes involved in disease pathogenesis and how their function is regulated.

Results

We performed an epigenome-wide association study, quantifying genome-wide patterns of DNA methylation in 67 migraine cases and 67 controls with a matching age and sex distribution. Association analyses between migraine and methylation probe expression, after adjustment for cell type proportions, indicated an excess of

SUBMITTER: Gerring ZF 

PROVIDER: S-EPMC5778740 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature