MS AHI1 genetic risk promotes IFNγ⁺ CD4⁺ T cells.

ABSTRACT:

Objective

To study the influence of the Abelson helper integration site 1 (AHI1) locus associated with MS susceptibility on CD4⁺ T cell function.

Methods

We characterized the chromatin state of T cells in the MS-associated AHI1 linkage disequilibrium (LD) block. The expression and the role of the AHI1 variant were examined in T cells from genotyped healthy subjects who were recruited from the PhenoGenetic Project, and the function of AHI1 was explored using T cells from Ahi1 knockout mice.

Results

Chromatin state analysis reveals that the LD block containing rs4896153, which is robustly associated with MS susceptibility (odds ratio 1.15, p = 1.65 × 10^-13), overlaps with strong enhancer regions that are pr

SUBMITTER: Kaskow BJ 

PROVIDER: S-EPMC5778810 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature