Dataset Information

Long-Term Exposure of Fine Particulate Matter Causes Hypertension by Impaired Renal D₁ Receptor-Mediated Sodium Excretion via Upregulation of G-Protein-Coupled Receptor Kinase Type 4 Expression in Sprague-Dawley Rats.

ABSTRACT:

Background

Epidemiological evidence supports an important association between air pollution exposure and hypertension. However, the mechanisms are not clear.

Methods and results

Our present study found that long-term exposure to fine particulate matter (PM_2.5) causes hypertension and impairs renal sodium excretion, which might be ascribed to lower D₁ receptor expression and higher D₁ receptor phosphorylation, accompanied with a higher G-protein-coupled receptor kinase type 4 (GRK4) expression. The in vivo results were confirmed in in vitro studies (ie, PM_2.5 increased basal and decreased D₁ receptor mediated inhibitory effect on Na⁺-K⁺ ATPase activity, decreased D₁ receptor expression, an

SUBMITTER: Lu X

PROVIDER: S-EPMC5778966 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Dataset Information

Long-Term Exposure of Fine Particulate Matter Causes Hypertension by Impaired Renal D₁ Receptor-Mediated Sodium Excretion via Upregulation of G-Protein-Coupled Receptor Kinase Type 4 Expression in Sprague-Dawley Rats.

Background

Methods and results

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Long-Term Exposure of Fine Particulate Matter Causes Hypertension by Impaired Renal D1 Receptor-Mediated Sodium Excretion via Upregulation of G-Protein-Coupled Receptor Kinase Type 4 Expression in Sprague-Dawley Rats.

Background

Methods and results

OmicsDI is part of the ELIXIR infrastructure

Tweets

Long-Term Exposure of Fine Particulate Matter Causes Hypertension by Impaired Renal D₁ Receptor-Mediated Sodium Excretion via Upregulation of G-Protein-Coupled Receptor Kinase Type 4 Expression in Sprague-Dawley Rats.