Modeling specific action potentials in the human atria based on a minimal single-cell model.

ABSTRACT: We present an effective method to model empirical action potentials of specific patients in the human atria based on the minimal model of Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology. In this model, three ionic are currents introduced, where each of it is governed by a characteristic time scale. By applying a nonlinear optimization procedure, a best combination of the respective time scales is determined, which allows one to reproduce specific action potentials with a given amplitude, width and shape. Possible applications for supporting clinical diagnosis are pointed out.

SUBMITTER: Richter Y 

PROVIDER: S-EPMC5779667 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature